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KMID : 1098420060140020101
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Korean Journal of Medicinal Crop Science
2006 Volume.14 No. 2 p.101 ~ p.106
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Comparison of Valerenic Acids and Valepotriates Production According to the Culture Conditions for Cultured Roots of Valeriana fauriei var. dasycarpa Hara
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Li Mei-Yang
Ahn Jun-Cheul
Kim Kwang-Soo
Kim Ok-Tae
Park Yoon-Jung
Hwang Baik
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Abstract
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We established a practical method for rapid and large-scale production of Valeriana fauriei var. dasycarpa Hara roots by bioreactor culture and confirmed valerenic acids and valepotriates production. We also compared valerenic acids and valepotriates production patterns according to various media conditions. Among the media tested, B5 medium gave the maximum biomass production of 101 g fresh weight, which was a 5.03-fold multiplication rate obtained 4 weeks after inoculation of 20 g of fresh weight. The best production of total valerenic acids (7.86;mg/l) and valepotriates (8.96;mg/l) was B5 medium.
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KEYWORD
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Valeriana fauriei var. dasycarpa Hara, valerenic acids, valepotriates, bioreactor culture, HPLC-PDA
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